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Children and adolescents lack safety data for this population

Mice expressing dominant-negative N-cadherin develop phenotype similar to IBD This study possibly provided the first experimental in vivo evidence that manipulating mucosal epithelial cell-to-cell adhesion can modulate mucosal barrier properties and that it promotes inflammation

Arch Pharm Res 43:920931

Phase 1, we're using the P450 enzyme

The electrogenic sodium bricarbonate cotransporter NBCe1 is a high-affinity bicarbonate carrier in cortical astrocytes
