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Nrf2 knockout rats and their wild type counterpart were obtained by cross breeding heterozygous animals generously provided by Julian Lombard and Aron Geurts, Medical College Wisconsin, Milwaukee [22]

In leukocytes, taurine acts to trap chlorinated oxidants (HOCl)

The substitution of four alanine residues for the PPQY motif resulted in the abolishment of these interactions, indicating that YAP1 recognizes NF1 via the PPQY motif (Fig

Fluorescence spectroscopy was crucial for discovery of protein conformational breathing, which was the foundation of the shift of the traditional view of proteins as rigid, static structures to a more accurate model of flexible, fluctuating molecules essential for biological function

doi: 10.1016/j.cub.2015.07.056 14 BeiF.LeeH