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A significant increase in mtDNA mutations has been reported in early-stage AD using high-precision next-generation sequencing methodologies, with evidence suggesting that these mtDNA mutations arise primarily from replication errors rather than oxidative damage [343]

Additionally, Samia Elbahnaswy et al

Lyophilized for Stability Freeze-dried format facilitates storage and controlled preparation
GPX4 immunolabeling with 3, 3-diaminobenzidine hydrochloride (DAB) containing NiCl 2 , in order to contrast with neuromelanin, coincided mostly within neuromelanin-positive neurons, and surprisingly was mostly associated with intracellular neuromelanin (Figure 1C, D)

The hard center (nucleus) of the lens is loosened from the rest of the cataract
