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Recently, Gogler and colleagues demonstrated that HSPA2 is a crucial factor in keratinocyte differentiation and migration to the strata spinosum and granulosum ( HSPA5/GRP78/BiP The accumulation of unfolded or misfolded proteins in the ER activates a signaling pathway known as the unfolded protein response (UPRER), which is regulated by three main sensors: protein kinase RNA-like ER kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6)

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We are pleased to have been involved in producing the new guideline, and we will be participating in producing a new Guideline on the Treatment of Cobalamin and Folate Disorders later this year.