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IGF-I is also positively associated with measures of aerobic fitness and muscular endurance [3]

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The frequency and extent of monitoring should be individualized based on patient-specific factors and the clinical indication for treatment

We further analyzed the expression of the rate-limiting key enzyme in each pathway (GPX4 for the glutathione pathway, HMG-CoA reductase [encoded by HMGCR ] for the mevalonate pathway, and TrxR [encoded by TXNRD1 ] for the thioredoxin pathway) in another single-nuclei dataset comprised of 22 NB patient tumors 32

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