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Cell lines and reagents The immortalized non-tumorigenic normal ovarian epithelial T72 cell line and the tumorigenic HRAS G12V -transformed T72Ras cell line were generated as previously described 12,32

10.1021/jm701490g 78 LukaszukA.DemaegdtH.Van Den EyndeI.VanderheydenP.VauquelinG.TourwD

One plausible explanation for these results is that the gpoA mutant is unable to effectively counteract the elevated ROS concentrations encountered within the intracellular environment of host cells, despite the partial compensatory activity of the TpxD and AhpD peroxidases (Fig

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