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Glucose uptake Compared with normal cells, cancer cells show a large appetite for glucose, since glucose is the main source of energy [35]

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This triggers inflammasome activation and an innate immune response.64 It is therefore possible that genetic susceptibility to APAP overdose could be determined by the ability of an individual to form the toxic imine metabolite determined by genotype for certain drug metabolism genes but also genotype for genes affecting the ability of cells to respond to oxidative stress, the innate immune system generally, and damage repair

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[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Funabiki K, Onishi K, Dohi K, Koji T, Imanaka-Yoshida K, Ito M, Wada H, Isaka N, Nobori T and Nakano T