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"Patients are injecting substances that have never been adequately tested in humans, based on marketing claims the available evidence simply does not support

3.2 Potential role of the gut-brain axis The gut-brain axis refers to the bidirectional communication network between the gastrointestinal system and the central nervous system (CNS)

[71] Another double-blind, placebo-controlled trial found that the test group comprising 65 patients who received 5% n-acetylcysteine gel for 8 weeks had significantly reduced the number of comedones compared to patients in the control group (34 patients) who received only placebo

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