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In mice, intravenous injection of fluorescently labeled pHLIP-Ku80 () targeted tumors and reduced Ku80 expression

Infrequent: abnormal coordination, abnormal EEG, abnormal gait, apathy, ataxia, coma, convulsions, delirium, delusion, dyskinesia, dysphonia, encephalopathy, euphoria, extrapyramidal disorder, hallucinations, hostility, hyperkinesia, hypnagogic hallucinations, hypokinesia, leg cramps, manic reaction, neuralgia, paranoia, phobic disorder, psychosis, sensory disturbance, somnambulism, stimulation, suicidal ideation, suicide attempt, teeth-grinding

This makes them particularly effective for individuals with absorption issues or severe deficiencies

However, this strategy was doubtful for some mephedrone samples and failed in most of the 2C-E samples