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The role of Ca 2+ ions in the function of NOS is related to the calmodulin subunits of NOS enzymes (see below)

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Despite its therapeutic potential, rhIGF-1 encounters several clinical limitations, primarily due to its structural homology with insulin, which may lead to hypoglycemia and growth hormone (GH) suppression (Jozefiak et al., 2021)

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Nitro-Fatty Acid Formation and Signaling

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