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The optimal timing strategy is the one that combines evidence-based principles with your individual needs, creating sustainable results that last far beyond any single cycle

Thus, the culture of erythroid progenitors and investigations of the expression profile of specific genes may make it easier to distinguish responders from nonresponders before the initiation of HU treatment in beta-thalassemia patients, but this possibility requires further study

Degradation of the BM, as expected during the initial phase of angiogenesis, however, may result in the generation of BM-derived antiangiogenic fragments such as canstatin, tumstatin, and arrestin, whose antiangiogenic functions were discussed in detail above

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