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PI3K activation initiates a phosphorylation cascade leading to the activation of Akt (also termed protein kinase B) and its downstream kinases phosphoinositide-dependant kinase 1 (PDK1), glycogen synthase kinase 3 (GSK3), p70 ribosomal protein S6 kinase (p70 S6K ), mammalian target of rapamycin (mTOR) and others [ 89 ]

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If you're prone to GERD or have a history of nighttime reflux, morning dosing may be preferable even if it's theoretically less efficient

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