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Gut-lung axis and dysbiosis in COVID-19

Abbreviations ALL: acute lymphoblastic leukemia CC: cancer cells CNS: central nervous system COX: cyclooxygenase DHA: docosahexaenoic acid EC: esophageal cancer EGCG: epigallocatechin gallate EPA: eicosapentaenoic acid IL: interleukin ITC: Isothiocyanate KD: ketogenic diet MUFA: monounsaturated fatty acids PUFA: polyunsaturated fatty acids SFA: saturated fatty acids TNF: tumor necrosis factor UGI: upper gastrointestinal Declarations Acknowledgement NPN would like to thank Mahidol University, Thailand, for providing Global Talent position

Despite the numerous possible p53 mutations that exist, most studies with APR-246 have focused on the hotspot mutations, namely the conformational mutant R175H [10,11,12,13]