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51 Its anti-atherogenic or athero-protective potential is, in part, thought to be due to the pivotal role it has in reverse cholesterol transport, returning cholesterol from cells in the periphery to the liver where it is then either re-used or excreted

Figueroa, A

M.SundqvistA.HeldinA.van DamH.KletsasD.HeldinC.-H.et al (2015)

The purified enzyme was completely inactive in the presence of molecular oxygen and the respective crystal structure revealed a substantial rearrangement of the active site loop region

Collectively, our observations show that mitochondrial functions are compromised in hlh-30 animals and that hlh-30 animals rewire their metabolism to largely depend on functional peroxisomes during starvation, underlining the importance of metabolic plasticity to maintain survival