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Shortened or dysfunctional telomeres is one way through which cells from organisms with renewable tissue can permanently withdraw from the cell cycle, other ways can include DNA damage, strong mitogenic signals, and disputed chromatin (Campisi, 2005)
doi: 10.1007/s10528-011-9472-2 148 FengCJinZChiXZhangBWangXSunLet al

Lancet 399 , 13131321 (2022)

mRNA Transcription, Translation, and Defects in Developmental Cognitive and Behavioral Disorders