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This can happen with improper storage, particularly if the medication was left out of the fridge for too long or exposed to extreme temperatures

Targeted p53 on small-molecules-induced ferroptosis in cancers

This drug delivery approach, using conventional multi-particulate technology, delivers physiological levels of hydrocortisone that commensurate with the circadian pattern of cortisol and a bioavailability close to that of the immediate-release formulation

However, if a patient had trouble breathing or rash immediately after a dose, that would indicate an allergy, not seen in the case here

10.1016/j.amjmed.2004.03.039 [DOI] [PubMed] [Google Scholar] 265.Fazal M