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Semaglutide requires weekly injections and often causes gastrointestinal side effects, while AOD-9604 is generally well-tolerated with minimal digestive impact

The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation

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Doses of pyridoxine as low as 5-10 mg can antagonize levodopas effect if carbidopa is not present, so caution is warranted and any supplemental B beyond the nutritional dose should be under medical guidance

When mice were orally administered 50 mg/kg of this compound, MNAM production decreased by approximately 80% within 2 h