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Description
Hepatology 2006;43:1145-51

Neurotherapeutics 16, 649665

Female SD rats were fed a standard diet or a cocoa butter-based HFD plus 10% liquid fructose for 3 months, which induced hepatic steatosis without obesity, inflammation, endoplasmic reticulum stress, or hepatic insulin resistance

In contrast, deletion or inhibition of GPX4 causes rapid H 2 O 2 accumulation and RIPK3-mediated necrosome activation 72,73

GH may act directly on skeletal cells having IGF-1-independent effects on bone growth (223, 224)