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For in vitro and ex vivo experiments the following compounds were used: TLR2/TLR1 agonist (Pam3CSK4 InvivoGen, USA, (1 g ml 1 )), rat recombinant IL-1 (Cat.# 400-01B PeproTech, USA, (10 ng ml 1 )) human recombinant receptor antagonist (IL-1ra) (PeproTech, USA, (100 ng ml 1 ))
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