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Moreover, preclinical studies of individual peptides have not reported significant acute toxicity

When HK-2 cells were treated with MLN4924, the UBE2m overexpression-induced increase in neddylation and expression of NEDD4 was rescued, as was the decrease in PPAR expression induced by NEDD4 elevation (Fig

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Acknowledgements The authors would like to express their heartfelt thanks to Chitkara College of Pharmacy, Chitkara University, Rajpura, Patiala, Punjab, India, for the vital infrastructure and support that made this research possible