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While we do not understand the mechanism for the increased activity of ether lipid synthesizing enzymes, the decreases in mRNAs for acl-7 , ads-1 , and fard-1 prompted by phenformin treatment and by overexpression of fard-1 alike invoke negative feedback of the end product(s) of ether lipid biogenesis on transcription of genes encoding ether lipid biosynthetic enzymes

Gorsich SW, Dien BS, Nichols NN et al (2006) Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae

Studies have shown that RNAi-mediated knockdown of NCOA4 expression significantly inhibits ferritinophagy, thereby reducing ferroptosis in mouse embryonic fibroblasts (Gao et al., 2016)

[DOI] [Google Scholar] 166.Suzuki D.O., Anselmo J., de Oliveira K.D., Freytag J.O., Rangel M.M., Marques J.L., Ramos A

The unique abundance of regulators of epigenetic mechanisms suggests that dysregulation of our epigenome could lead to altered synaptic plasticity and impaired learning and memory, as is observed in sleep-deprived individuals