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Symptoms that may indicate low Vitamin B levels include fatigue, depression, low blood pressure, constipation, memory loss, weakness, sore tongue, tingling and numbness in fingers and toes, mood changes and difficulty walking

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Potentiation of anti-myeloma activity of daratumumab with combination of cyclophosphamide, lenalidomide or bortezomib via a tumor secretory response that greatly augments macrophage-induced ADCP
