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When the rate of ROS generation exceeds the clearance capacity of the body, there is an excessive accumulation of ROS, which react with Fe 2+ to induce lipid peroxidation, thereby initiating ferroptosis

Macrophages detect these apoptotic cells using specific efferocytic receptors, such as Mer tyrosine kinase (MERTK) and T-cell immunoglobulin and mucin domain containing-4 (TIM-4), which recognize PS directly or indirectly through bridging molecules like Growth Arrest-specific gene 6 (Gas6) and Protein S [24, 30]

Longitudinal association between sarcopenia and cognitive impairment among older adults in Rural Malaysia

Additionally, specific interactions between disease-related proteins and mitochondria contribute to the progression of these disorders [96]