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We further demonstrate that a T291A/T292A double variant of ArfGAP1 induces an intermediate level of Golgi fragmentation relative to WT and 3A ArfGAP1 (Supplementary Figure S1)

Activated myelin-specific CD4 + T cells that react to myelin antigens are primarily responsible for this reaction [36]

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The resultant lactylated/acetylated HMGB1, released via macrophage-derived exosomes, subsequently enhances endothelial cell permeability

Optional research biomarkers: senescence markers (p16^INK4a, SA--gal), SASP cytokine profile (IL-6, IL-1, MMPs) if lab resources permit
