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For instance, resveratrol reestablishes the balance of mitochondria fissionfusion and regulates autophagic flux and mitochondrial biosynthesis through the SIRT1/SIRT3-Mfn2-Parkin-PGC-1 pathway in myocardial IRI [132]
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These clinical challenges to address the interplay between metabolic and neurodegenerative disorders require innovative strategies that can focus upon the underlying mechanisms of aging, oxidative stress, cell senescence, and cell death
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