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Although the expressivity of NF-1 varies considerably, even among individuals in the same family who are genotypically identical, the disorder is considered to be 100% penetrant

It should also be manufactured from high-quality, pure ingredients with minimal ideally zero harmful additives

Thats not an in vitro petri dish

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As regards the pathogenic mechanisms, the occurrence of an oxidant stress (resulting from an impaired homocysteine metabolism, which modifies the redox status of extra- and intracellular thiols and thus alters the intracellular redox potential) might play a central role in moderate hyperhomocysteinemia-mediated vascular disorders