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Interest in azanone donors and in the biological chemistry of HNO has increased significantly during the last 2 decades, due to the beneficial pharmacological effects of its donors in the treatment of heart failure
2) amino acid modification
doi: 10.1182/blood-2005-08-3099 141 HeR.SangH.YeR
doi: 10.1677/JOE-09-0391
Supplementation with antioxidants, such as N-acetylcysteine (NAC), can improve mood and reduce oxidative stress in people with depression [220]
