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The clinical picture is the most important factor in assessing the significance of results of blood tests assessing cobalamin (B 12 ) status because there is no gold standard test to define deficiency Neurological symptoms resulting from B 12 deficiency may take several months or even years to resolve completely Measuring serum biomarkers such as B 12 or methylmalonic acid is neither helpful nor indicated in assessing or monitoring clinical improvement, neither is titration of injection frequency based on biomarker assessment Self-administration of intramuscular B 12 injections can lead to greater patient satisfaction and better health outcomes What is vitamin B 12

Musculoskeletal injuries, gastrointestinal disorders, and vascular conditions represent logical initial targets given the preclinical database and potential clinical impact

Methylcobalamin is best, unless you suffer from Lebers hereditary optic neuropathy (1 in 30,000 to 50,000 people), where hydroxy B12 is safer

Cycles often run 8-12 weeks with breaks between

This involves injecting cyanocobalamin (the synthetic form of B12) into the muscle so that it enters the bloodstream directly