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In PD, misfolded syn and neuronal damageassociated molecules (e.g., ATP, HMGB1) activate microglia through pattern recognition receptors including TLR2 and TLR4 [14], triggering a proinflammatory phenotype with cytokines (TNF and IL1) and ROS release [15]

doi: 10.1024/0300-9831/a000149 206

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A vaccine based on conserved long peptides (Flu-v, PepTcell SEEK) was tested in a human challenge study with H1N1 challenge virus and reduced mild to moderate disease [119]

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