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Two independent reviewers screened articles by title and abstract, followed by full-text assessment to exclude studies not primarily related to DPN, with disagreements resolved through consensus

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While vitamin E supplementation could simply restore vitamin levels in AD, baseline vitamin E levels are often not checked

They'll ask about your medical history and do a nail exam to check your nail line for: Color How even and regular the color looks Line width and shape Blurry or fuzzy borders on the band Hutchinson's sign, a dark band that spreads to the nearby skin around your nail Your doctor can use the "ABCDEF rule" for nail melanoma to check for any abnormal longitudinal melanonychia bands on your nails: A