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This is seen potentially due to how MPP+ promotes the breakdown of HDAC1 and HDAC2 via autophagy, a bodily process of cycling out old cells to make room for newer, healthier cells

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therefore, three strains of Lactobacillus , each shown alone to have a protective effect against the development of EAE when administered before disease onset, were shown to inhibit established disease when administered as a therapeutic mixture

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