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MS patients may have vision disturbances, motility disorders, or hearing problems

Ungvari Z, Tarantini S, Sorond F, Merkely B, Csiszar A

Additional genetic polymorphisms occurring in choline and one-carbon metabolic pathways may alter the dietary requirement for choline and thus increase the likelihood of developing signs of deficiency when choline intake is inadequate (9, 20, 21)

Orphanet J Rare Dis 18(1):118 Morgan NV, Westaway SK, Morton JE, Gregory A, Gissen P, Sonek S et al (2006) PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron

[60] these functional impairments involve impaired dopamine neurotransmission in the mesocorticolimbic projection and norepinephrine neurotransmission in the noradrenergic projections from the locus coeruleus to the prefrontal cortex