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However, as explained before, these chelators often exhibit suboptimal in vivo stability when complexed with copper, largely due to transchelation to serum proteins, leading to off-target accumulation, particularly in the liver

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In the FY 2023 Hospice Wage Index and Payment Rate Update and Hospice Quality Reporting Requirements final rule (87 FR 4566) (Hospice rule), we affirmed our intention to initiate a hospice Technical Expert Panel (TEP) to provide input on the structure and methodology of the SFP