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A more comprehensive strategy to avoid GSH-based platinum drug resistance mechanisms is based on suppression of GSH synthesis in the malignant tissue, which wouldbesides GST-catalyzed drug conjugation in cancer cellsalso target extracellular oxaliplatin inactivation via GSH adduct formation 20

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17,39 RNA velocity analyses further revealed that aged MuSCs exhibit delayed differentiation, with elevated expression of Snai2 and diminished expression of Myog and Mef2c

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