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Nrf2 controls the basal and induced expression of an array of antioxidant response element-dependent genes to regulate the physiological and pathophysiological outcomes of oxidant exposure. Nrf2 is responsible for regulating an extensive panel of antioxidant enzymes involved in detoxification and elimination of oxidative stress and has been extensively studied in disease contexts. Clearly it is a main regulator of antioxidant stress response

, Li L., Chen L., et al

doi: 10.1212/WNL.0000000000005771

These bioactive supplements are commonly integrated into a variety of food matrices, including beverages (juices, teas, and smoothies) and dairy products (yogurt and milk), where they effectively modulate ACE inhibitory activity [87, 149]

During ischemia, a large increase in the antioxidant defense system, such as glutathione augmentation, has been seen in an attempt to deal with oxidative stress [156,157]