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It may also be part of therapy to treat Leber optic atrophy (an inherited optic neuropathy associated with a deficiency in vitamin B12)

doi: 10.1111/j.1440-1746.2006.04351.x

While vitamin B12 supports cellular energy metabolism, supplementing B12 in a patient who is not deficient does not increase metabolic rate or cause fat loss

In experimental models, MOTS-c has been associated with improved muscle glucose handling and adaptations under metabolic strain, suggesting it may contribute to systemic energy balance

Medically supervised weight loss can be a potentially effective method for shedding pounds and inches when used together with diet modification