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Eprenetapopt (APR-246) acts synergistically with azacitidine when used to treat TP53 -mutant MDS and AML 13,33
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However, the interaction between the carnitine pool and the endocrine system is complex, and more studies are needed to understand the specific mechanisms involved
Moreover, GSH plays an important role in protecting neuronal cells against nitrosative stress, preventing the production of the neurotoxic and pro-inflammatory compound peroxynitrite in a reaction catalyzed by GPx [55,58]
