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Further evidence supporting the potential in situ deleterious effects of APAP in brain comes from studies showing that APAP increases neuronal CYP2E1 enzymatic activity and protein levels, leading to neuronal cell death through mitochondrial-mediated mechanisms that involve cytochrome c release and caspase 3 activation (130)

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10.1186/s13020-022-00653-0 [DOI] [PMC free article] [PubMed] [Google Scholar] Teruel-Andreu C., Andreu-Coll L., Lpez-Lluch D., Sendra E., Hernndez F., Cano-Lamadrid M

Sdha detection was performed on FoB from total spleen with the MitoBiogenesis Flow Cytometry Kit (Abcam ab168540) following the manufacturers instructions

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