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In order to further confirm that PXR is an upstream regulator for MDM2, we transfected siRNA targeting PXR, and the results showed that PXR knockdown resulted in downregulation of ATF3 and upregulation of MDM2 ( Figure 5H , lane 2 vs
THC is distributed and metabolized in a region-specific manner, with highest levels in the hippocampus
It is thought that the pro-oxidant effect caused by MSG will increase oxidative stress and trigger a faster and more destructive progression of such a scenario
Plant Genome 18, e20520
doi: 10.1128/JB.01655-07 177 ZhouE.SeminaraA
