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In rat cardiomyocytes, zinc overload elevates ROS and disrupts mitochondrial membrane potential, triggering PINK1/Parkin-mediated mitophagy and impairing mitochondrial dynamics and biogenesis, with mitofusin 2 (Mfn2) playing a protective role in mitigating zinc-induced mitochondrial damage 151

Infertility Inform patients that chronic use of opioids may cause reduced fertility

PLoS ONE 5 , e12322 (2010)

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Therefore, it is better to use specific TKIs based on the overexpressed tyrosine kinase in each cancer type [165]
