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4 Involvement of cytokines in the mechanism of RA remission 4.1 Tumor necrosis factor Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in many aspects of immune regulation, and anti-TNF biotherapies are considered a breakthrough in the treatment of RA (Kalliolias and Ivashkiv, 2015

doi: 10.1080/10715769800300101

(2023) 37:e23130

It is therefore suggesting that the slight change of relaxation observed in the aorta without endothelium ex vivo might be due to some mechanism unrelated to the direct nitric oxide stimulation which needs further investigation

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