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Furthermore, in animal experiments, it was observed that elevated neutrophil infiltration into muscle, kidney, and liver may exacerbate tissue injury (149, 150), and neutrophil depletion can be a factor alleviating liver damage following exhaustive exercise (150)

the subject in need thereof may be a subject identified as being particularly responsive to treatment according to the methods described herein, i.e

Arbutin, the b-D-glucopyranoside derivative of hydroquinone, is a naturally occurring plant-derived compound found in the dried leaves of a number of different plant species including, bearberry (Arctostaphylos uva-ursi), blueberry, cranberry, and pear trees

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PMC 3278486