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Contribution of intrinsic lactate to maintenance of seizure activity in neocortical slices from patients with temporal lobe epilepsy and in rat entorhinal cortex

pharmacological disruption of this loop restores mitochondrial integrity and alleviates psoriasis like skin pathology

A known effector of PI3K, ARAP3, a GAP for small GTPases like RhoA and Arf6 has been shown to be a negative regulator of IgG IC-activated ROS production (Gambardella et al., 2013)

However, this would represent an off-label, experimental approach that falls well outside current NICE guidance or standard NHS practice, and should only ever be considered within a formal clinical trial or with robust multidisciplinary oversight, documented informed consent, and a clear monitoring plan

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