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Description
in PDAC, GOT1 and ME1 maintain the NADPH/NADP + ratio via the malate-aspartate shuttle by maintaining GSH levels 56
Metkar, M., Pepin, C
To address this, we additionally deleted the gene coding for Ggt in these cells and analyzed reduction of Grx1-roGFP2 by exogenous GSH in the resulting gshA gsiC ggt triple deletion mutant
Proteins in the extracellular space represent a large store of cysteine available for cells to use for proliferation and survival
Assessment of Reliability
