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The side effect accumulation over time (progressive joint discomfort, worsening injection site reactions, increasing hypoglycemic frequency) makes extended use impractical for most

Front Plant Sci 4: 111 (read) Douch T, San Clemente H, Burlat V, Roujol D, Valot B, Zivy M, Pont-Lezica R, Jamet E (2013) Brachypodium distachyon as a model plant towards improved biofuel crops : Search for secreted proteins involved in biogenesis and disassembly of cell wall polymers

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doi: 10.3390/md18090474