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1,2 The IGFBPs may modulate the action of IGFs in several different ways: Inhibitory Model - IGFBPs prevent IGF/receptor association Enhancing Model - IGFBPs transport IGFs and facilitate binding with IGF receptors IGF Receptor-Independent Model - Product of direct IGFBPs/IGFBP receptor interaction Proteolytic Cleavage of IGFBP - Cleaved into lower affinity fragments which increases freely circulating, bioavailable IGF IGF-1 IGF-1 (Somatomedin C) is one of several growth factors necessary for normal human development

[DOI] [PubMed] [Google Scholar] 180.Jensen DE, Belka GK, Du Bois GC

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This means that R-ALA can achieve the same effects as ALA but at lower doses

doi: 10.1158/1078-0432.CCR-12-2638 98 GuanXMorrisME