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Possible contribution of IGF-1 to depressive disorder

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The alkaloids dose-dependently increased MDR-MDCK cell uptake of calcein-AM, with mitragynine and 7-hydroxymitragynine EC 50 of 18.2 and 32.4 M respectively, comparable to the P-gp inhibitor verapamil which shown EC 50 of 22.3 M ( Another important ABC transporter which expression includes at the gastrointestinal tract and at the BBB is the breast cancer resistance protein (BCRP)

It works through nitric oxide modulation, VEGF-driven angiogenesis, and the FAK-paxillin cell migration pathway