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In summary, the above findings suggest that the ascending slope in the proposed U-shaped susceptibility to cancer curve that occurs at high levels of Nrf2 activity might arise as a consequence of the CNC-bZIP transcription factors contribution to inhibition of apoptosis, increase in cell proliferation (in part by directing metabolism toward NADPH generation and improving ATP synthesis for the synthesis of macromolecules), and activation of PAH and nitrosamine chemical carcinogens, as well as its possible influence on dedifferentiation that might allow developmental reprogramming during oncogenesis

The randomization sequence was kept in a sealed, opaque envelope, which was opened sequentially by the recruiting team upon patient enrollment

Langmuir 32 , 27312736 (2016)

GSH also protects the lungs against RS-induced damage (e.g., in cystic fibrosis, where patients suffering from this condition tend to have lower GSH levels) (Halliwell and Gutteridge, 2015)

It also activates many important functions of the immune system