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Neroni B, Evangelisti M, Radocchia G, et al

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TFAM is almost exclusively present in a DNA-bound form (Takamatsu et al., 2002), and degradation of TFAM proteins by mitochondrial matrix proteases directly affects mtDNA copy number (Matsushima et al., 2010)

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The natural pathogenesis of HIV consists of three stages: 1) the primary HIV infection phase, 2) the asymptomatic chronic phase, and 3) the late HIV symptomatic phase, which leads to an immunocompromised state resulting in increased susceptibility to opportunistic infections

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