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Lack of fenestrations Fenestrations are ultramicroscopic pores in the plasma membranes of endothelial cells that facilitate the rapid, but nonspecific, exchange of molecules between blood vessels and surrounding tissues (Fidanboylu, 2013)

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Nanotechnology has emerged as a transformative tool to address these problems, offering solutions such as liposomal, polymeric nanoparticulate, dendritic, and micellar systems for solubilization, stabilization, and site-specific delivery of antioxidants